"The U.S. role is prominent in the aggression against the peoples of the region. Especially against the Yemenis," Irlu wrote in his Twitter account.
"What is happening in the Saudi siege & aggression against Yemen is merely the implementation of the American Zionist policies," he added.
Saudi Arabia and its regional allies attacked Yemen in March 2015 to bring back to power the deposed president of Yemen Abdrabbuh Mansour Hadi.
Since then, the invaders have committed horrible war crimes against Yemeni civilians.
Earlier, Iranian Foreign Minister Mohammad Javad Zarif, too, in an online conversation with his Yemeni counterpart Hisham Sharaf said the continuation of aggression and cruel blockade by the Saudi coalition in Yemen and confiscating vessels carrying food and fuel is not acceptable.
Iran believes that the only way for establishing stability in Yemen is to preserve territorial integrity and unity among all Yemeni groups and to hold intensive political talks among different parties for establishing the united government, he added.